Role of LAP+CD4+ T cells in the tumor microenvironment of colorectal cancer

Table 3 Proportions of LAP⁺CD4⁺ T cells in tumor tissues and in relation to clinicopathological characteristics

	n	LAP+CD4+ Treg (%)	t	P value	95%CI
Age, yr
< 60	29	11.15 ± 2.03	0.747	0.458	-1.35-2.94
≥ 60	21	11.96 ± 4.51
Sex
Male	31	11.37 ± 3.24	0.444	0.659	-1.60-2.50
Female	19	11.82 ± 3.89
Location
Colon	22	10.35 ± 3.45	0.652	0.517	-1.11-2.18
Rectum	28	11.89 ± 3.17
TNM stage
I/II	23	8.45 ± 2.98	4.973	0.000	3.85-9.07
III/IV	27	14.90 ± 5.58
Pathological pattern
Tubular/ papillary	43	11.09 ± 3.54	1.335	0.188	-0.73-3.60
Myxoma/ ring cell	7	12.83 ± 3.26
Differentiation
High	42	10.50 ± 3.22	0.877	0.385	-1.45-3.70
Low	8	12.43 ± 3.87
Metastasis
Yes	9	12.51 ± 4.17	4.322	0.000	2.49-6.82
No	41	7.85 ± 2.61
Ileus
Yes	9	12.22 ± 3.49	0.904	0.470	-1.30-3.44
No	41	11.15 ± 3.14
CEA (ng/mL)
≤ 5	34	9.94 ± 3.15	2.692	0.010	0.81-5.58
> 5	16	13.13 ± 4.06
CA199 (U/mL)
≤ 37	32	11.34 ± 3.21	0.854	0.370	-1.51-3.85
> 37	18	12.42 ± 4.35