Clinical impact of immunomonitoring in the treatment of inflammatory bowel disease

Table 2 Detecting anti-tumor necrosis factor-α antibody levels

Ref.	Technique	Key points
Van Stappen et al[30]	Solid-phase ELISA	Lacks the ability to detect ADA in the presence of drug
Gils et al[25]	Solid-phase ELISA
Bloem et al[31]	Drug tolerant ELISA
Imaeda et al[23]	ELISA	Measures AAAs in the presence of free ADA
Van Stappen et al[32]	ELISA	Converts drug-sensitive bridging ELISA into a drug-tolerant bridging ELISA

ELISA: Enzyme-linked immunosorbent assay; ADA: Anti-tumor necrosis factor-α; AAA: Antibodies against adalimumab.