Hwangryunhaedok-tang induces the depolarization of pacemaker potentials through 5-HT3 and 5-HT4 receptors in cultured murine small intestine interstitial cells of Cajal

Figure 2 Effects of 5-HT receptor antagonists on water extract of Hwangryunhaedok-tang-induced pacemaker potential depolarizations in the cultured interstitial cells of Cajal of murine small intestine. A: Y25130 (a 5-HT3 receptor antagonist) inhibited HHTE-induced responses. B: A 5-HT4 receptor antagonist, RS39604, blocked HHTE-induced responses. C: A 5-HT7 receptor antagonist, SB269970, did not block HHTE-induced responses. D and E responses to 5-HT receptor antagonists are summarized. Bars indicate the means ± SEMs. ^aP < 0.05 and ^eP < 0.001: Significantly different from nontreated controls. CTRL: Control; HHTE: Water extract of Hwangryunhaedok-tang.