Clinical outcomes of isolated renal failure compared to other forms of organ failure in patients with severe acute pancreatitis

Table 2 Severity predictors, imaging findings, and clinical outcomes among acute pancreatitis patients with isolated organ failure, multi-organ failure, and no persistent organ failure n (%)

	IOF	MOF	P value	No OF	P value
	n = 43	n = 68		n = 389
SIRS score on admission ≥ 2	23 (53.5)	45 (66.2)	0.18	107 (27.5)	< 0.001
SIRS score at 48 h of admission ≥ 2	26 (60.5)	52 (76.5)	0.07	84 (21.6)	< 0.001
Mean IVF the first 24 h in liters (SD)	4.38 (1.98)	5.04 (1.79)	0.41	3.79 (1.5)	0.23
ICU admission	36 (83.7)	68 (100)	0.001	50 (12.9)	< 0.001
Median ICU LOS in days (IQR)	6 (2-14.4)	18.5 (10-35)	< 0.001	0	< 0.001
Need for nutritional support	38 (88.4)	58 (85.3)	0.64	80 (20.6)	< 0.001
Pancreatic necrosis1	28/39 (71.8)	45/54 (83.3)	0.18	80/251 (31.9)	< 0.001
Infected necrosis1	5/39 (12.8)	21/54 (38.9)	0.006	11/164 (6.7)	0.2
Need for drainage or debridement	13 (30.2)	38 (55.9)	0.008	31 (8)	< 0.001
Extra-pancreatic infections	8 (18.6)	30 (44.1)	0.006	27 (6.9)	0.008
Median LOS in days (IQR)	20 (16-32)	37 (25-53)	< 0.001	6 (4-9)	< 0.001
Mortality	0	22 (32.4)	< 0.001	0

¹Denominators reflect number of patients with available contrast-enhanced computed tomography scan. P values: 1^st column reflects comparison of IOF to MOF, and 2^nd column reflects comparison of IOF to OF. AP: Acute pancreatitis; IOF: Isolated organ failure; MOF: Multi-organ failure; OF: Organ failure; SIRS: Systemic inflammatory response syndrome; IVF: Intravenous fluids; ICU: Intensive care unit; LOS: Length of stay; IQR: Interquartile range.