Gut barrier failure biomarkers are associated with poor disease outcome in patients with primary sclerosing cholangitis

Table 2 Gut failure markers in patients with primary sclerosing cholangitis and various healthy and diseases control groups n (%)

	PSC (n = 67)	UC (n = 172)	P value1	HC (n = 153)	P value1
AAA
IgA	19 (28.4)	19 (11.2)	0.003	5 (4.4)	< 0.001
IgG	17 (25.4)	7 (4.1)	< 0.001	3 (2.7)	< 0.001
IgA or IgG	27 (40.3)	25 (14.7)	< 0.001	7 (6.2)	< 0.001
IgA and IgG	9 (13.4)	1 (0.6)	< 0.001	1 (0.9)	0.001
AGA
IgA	6 (9.0)	6 (3.5)	0.101	4 (2.6)	0.071
IgG	14 (20.9)	15 (8.7)	0.014	9 (5.9)	0.002
IgA or IgG	15 (22.4)	20 (11.6)	0.042	11 (7.2)	0.003
IgA and IgG	5 (7.5)	1 (0.6)	0.007	2 (1.3)	0.029

¹P-values pertain to comparisons between PSC and the given control group. AAA IgA/G was measured in 170 patients with UC and 113 healthy controls. PSC: Primary sclerosing cholangitis; UC: Ulcerative colitis; HC: Healthy controls; AAA: Anti-F-actin antibody; AGA: Anti-gliadin antibody.