Gut barrier failure biomarkers are associated with poor disease outcome in patients with primary sclerosing cholangitis

Table 1 Clinical and laboratory characteristics of primary sclerosing cholangitis patients

	Patients with PSC (n = 67)
Age at diagnosis (yr)	25 (17-36)
Disease duration (yr)	6 (3-10)
Children	10 (14.5)
Male	49 (71.0)
Cirrhosis	14 (20.3)
Prior OLTx	4 (5.8)
IBD	52 (75.4)
Crohn's Disease	17 (32.7)
Ulcerative Colitis	35 (67.3)
Overlap syndrome	9 (13.0)
Small duct PSC	5 (7.2)
Celiac disease	1 (1.5)
Albumin (g/L)	44 (40-47)
Bilirubin (μmol/L)	15 (11-22)
ALT (U/L)	52 (26-99)
AST (U/L)	41 (28–66)
GGT (U/L)	152 (60-310)
ALP (U/L)	524 (307-822)
INR	1 (1.0-1.2)
Platelet (109/L)	252 (173-319)
Mayo risk score	-0.595 (-1.194-0.102)
Atypical P-ANCA IgG	57 (85.1)
EMA IgA	1 (1.5)
EMA IgG	1 (1.5)

Data are summarized as median, (interquartile range: 25^th-75^th percentile) or as n (%). ALP: Alkaline phosphatase; ALT: Alanine transaminase; AST: Aspartate transaminase; GGT: Gamma glutamyl transferase; INR: International normalized ratio; P-ANCA: Perinuclear anti-neutrophil cytoplasmic antibodies; EMA: Anti-endomysial antibodies; OLTx: Orthotopic liver transplantation; IBD: Inflammatory bowel disease; IQR: inter-quartile range.