Genetic polymorphisms of MAFK, encoding a small Maf protein, are associated with susceptibility to ulcerative colitis in Japan

Table 2 Characteristics of the subjects and allelic frequency

	Controls	IBM controls	UC cases
Number of sample	748	360	226
Mean age ± SD	57.1 ± 17.0	58.5 ± 14.5	40.7 ± 14.2a
(age of onset)			(33.6 ± 13.5)
Male:female	438:310	165:195b	125:101
rs4268033 G>A
GG	366	184	101
GA	324	156	89
AA	58	20	36c
A allele freqency	29.40%	27.20%	35.6%d
rs3735656 T>C
TT	329	168	103
TC	346	162	90
CC	73	30	33
C allele freqency	32.90%	30.80%	34.50%
rs10226620 C>T
CC	345	171	104
CT	328	159	94
TT	75	30	28
T allele freqency	32.00%	30.40%	33.20%

^aP < 0.0001 vs controls and IBM controls;

^bP < 0.0001 vs controls and P = 0.027 vs UC cases;

^cP = 0.0005 vs controls and P < 0.0001 vs IBM controls;

^dP = 0.015 vs controls and P = 0.0027 vs IBM controls. UC: Ulcerative colitis.