Celecoxib-induced gastrointestinal, liver and brain lesions in rats, counteraction by BPC 157 or L-arginine, aggravation by L-NAME

doi:10.3748/wjg.v23.i29.5304

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 7, 2017; 23(29): 5304-5312
Published online Aug 7, 2017. doi: 10.3748/wjg.v23.i29.5304

Table 3 Brain lesions assessment after celecoxib, BPC 157, L-NAME, L-arginine

Medication (/kg intraperitoneally) immediately after celecoxib 1 g/kg intraperitoneally	Time after celecoxib	Brain lesions assessment
		Microscopic assessment, Score (0-4),Min/Med/Max		Microscopic assessment, Score (0-3), Min/Med/Max
		Purkinje cells (red neurons)	Cerebral cortex (red neurons)	Edema
Control, saline 5 mL	24 h	2/2/2	2/2/2	0/0/0
Control, saline 5 mL	48 h	2/2/3	2/2/3	0/0/0
BPC 157 10 μg	24 h	0/0/0^a	0/1/1^a	0/0/0
BPC 157 10 μg	48 h	0/1/1^a	0/1/1^a	0/0/0
BPC 157 10 ng	24 h	0/1/1^a	0/1/1^a	0/0/0
BPC 157 10 ng	48 h	0/1/1^a	1/1/1^a	0/0/0
BPC 157 1 ng	24 h	0/1/1^a	0/1/1^a	0/0/0
BPC 157 1 ng	48 h	0/1/1^a	0/1/1^a	0/0/0
L-NAME 5 mg	24 h	2/2/3	2/2/3	0/0/0
L-NAME 5 mg	48 h	2/3/3	2/3/3	0/0/0
L-arginine 100 mg	24 h	1/2/2	1/2/2	0/0/0
L-arginine 100 mg	48 h	1/2/2^a	1/2/2^a	0/0/0
L-NAME 5 mg + L-arginine 100 mg	24 h	2/2/2	2/2/2	0/0/0
L-NAME 5 mg + L-arginine 100 mg	48 h	2/2/2	2/2/2	0/0/0
L-NAME 5 mg + BPC 157 10 μg	24 h	1/1/1^a	1/1/2^a	0/0/0
L-NAME 5 mg + BPC 157 10 μg	48 h	1/1/2^a	1/1/2^a	0/0/0
L-NAME 5 mg + BPC 157 10 ng	24 h	1/1/1^a	1/1/2^a	0/0/0
L-NAME 5 mg + BPC 157 10 ng	48 h	1/1/2^a	1/1/2^a	0/0/0
L-arginine 100 mg+ BPC 157 10 μg	24 h	0/1/1^a	0/1/1^a	0/0/0
L-arginine 100 mg+ BPC 157 10 μg	48 h	1/1/2^a	0/1/1^a	0/0/0
L-arginine 100 mg + BPC 157 10 ng	24 h	0/1/1^a	0/1/1^a	0/0/0
L-arginine 100 mg + BPC 157 10 ng	48 h	1/1/2^a	1/1/1^a	0/0/0
L-NAME 5 mg + L-arginine 100 mg + BPC 157 10 μg	24 h	1/1/2^a	1/1/1^a	0/0/0
L-NAME 5 mg + L-arginine 100 mg + BPC 157 10 μg	48 h	1/1/2^a	1/1/1^a	0/0/0
L-NAME 5 mg + L-arginine 100 mg + BPC 157 10 ng	24 h	1/1/2^a	1/1/1^a	0/0/0
L-NAME 5 mg + L-arginine 100 mg + BPC 157 10 ng	48 h	1/1/2^a	1/2/1^a	0/0/0

^aP < 0.05 vs control.

Citation: Drmic D, Kolenc D, Ilic S, Bauk L, Sever M, Zenko Sever A, Luetic K, Suran J, Seiwerth S, Sikiric P. Celecoxib-induced gastrointestinal, liver and brain lesions in rats, counteraction by BPC 157 or L-arginine, aggravation by L-NAME. World J Gastroenterol 2017; 23(29): 5304-5312
URL: https://www.wjgnet.com/1007-9327/full/v23/i29/5304.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i29.5304