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©The Author(s) 2017.
World J Gastroenterol. Aug 7, 2017; 23(29): 5304-5312
Published online Aug 7, 2017. doi: 10.3748/wjg.v23.i29.5304
Published online Aug 7, 2017. doi: 10.3748/wjg.v23.i29.5304
Medication (/kg intraperitoneally) immediately after celecoxib 1 g/kg intraperitoneally | Time after celecoxib | Liver lesions assessment | ||||
Microscopic assessment, Score (0-3), Min/Med/Max | Serum enzymes values (IU/L), means ± SD | |||||
steatosis | congestion | necrosis | ALT | AST | ||
Control, saline 5 mL | 24 h | 2/2/3 | 2/2/3 | 2/2/3 | 352 ± 12 | 75 ± 8 |
48 h | 2/3/3 | 2/2/3 | 2/2/3 | 356 ± 18 | 84 ± 9 | |
BPC 157 10 μg | 24 h | 1/1/1a | 1/1/2a | 1/1/1a | 138 ± 14a | 41 ± 11a |
48 h | 1/1/1a | 1/1/2a | 1/1/1a | 63 ± 12a | 35 ± 12a | |
BPC 157 10 ng | 24 h | 1/1/1a | 1/1/2a | 1/1/1a | 154 ± 13a | 45 ± 8a |
48 h | 1/1/2a | 1/1/2a | 1/1/1a | 72 ± 19a | 40 ± 7a | |
BPC 157 1 ng | 24 h | 1/1/1a | 1/1/2a | 1/1/1a | 170 ± 15a | 48 ± 10a |
48 h | 1/1/2a | 1/1/2a | 1/1/1a | 80 ± 15a | 43 ± 8a | |
L-NAME 5 mg | 24 h | 2/3/3 | 2/2/3 | 2/2/3 | 375 ± 11 | 86 ± 12 |
48 h | 3/3/3 | 2/3/3 | 2/2/3 | 400 ± 12 | 80 ± 10 | |
L-arginine 100 mg | 24 h | 1/2/2a | 1/2/2a | 1/2/2a | 315 ± 14a | 68 ± 14a |
48 h | 1/2/2a | 1/2/2a | 1/2/2a | 300 ± 21a | 65 ± 10a | |
L-NAME 5 mg + L-arginine 100 mg | 24 h | 1/2/2a | 1/2/2a | 1/2/2a | 293 ± 17a | 68 ± 9a |
48 h | 2/2/2 | 2/2/3 | 2/2/2 | 270 ± 15a | 73 ± 11a | |
L-NAME 5 mg + BPC 157 10 μg | 24 h | 1/1/1a | 1/2/2a | 1/1/1a | 170 ± 15a | 69 ± 9a |
48 h | 1/1/2a | 1/2/2a | 1/1/1a | 150 ± 12a | 55 ± 13a | |
L-NAME 5 mg + BPC 157 10 ng | 24 h | 1/1/1a | 1/2/2a | 1/1/1a | 210 ± 16a | 70 ± 7a |
48 h | 1/1/2a | 1/2/2a | 1/1/1a | 182 ± 14a | 60 ± 8a | |
L-arginine 100 mg + BPC 157 10 μg | 24 h | 1/1/1a | 1/1/1a | 1/1/1a | 165 ± 25a | 55 ± 8a |
48 h | 1/1/2a | 1/1/1a | 1/1/1a | 160 ± 18a | 45 ± 8a | |
L-arginine 100 mg + BPC 157 10 ng | 24 h | 1/1/1a | 1/1/2a | 1/1/1a | 190 ± 11a | 63 ± 10a |
48 h | 1/1/2a | 1/1/2a | 1/1/1a | 170 ± 13a | 55 ± 9a | |
L-NAME 5 mg + L-arginine 100 mg + BPC 157 10 μg | 24 h | 1/1/2a | 1/1/2a | 1/1/1a | 167 ± 11a | 57 ± 10a |
48 h | 1/1/2a | 1/1/2a | 1/1/1a | 176 ± 14a | 57 ± 8a | |
L-NAME 5 mg + L-arginine 100 mg + BPC 157 10 ng | 24 h | 1/1/2a | 1/1/2a | 1/1/1a | 202 ± 9a | 62 ± 7a |
48 h | 1/1/2a | 1/1/2a | 1/1/1a | 190 ± 12a | 65 ± 8a |
- Citation: Drmic D, Kolenc D, Ilic S, Bauk L, Sever M, Zenko Sever A, Luetic K, Suran J, Seiwerth S, Sikiric P. Celecoxib-induced gastrointestinal, liver and brain lesions in rats, counteraction by BPC 157 or L-arginine, aggravation by L-NAME. World J Gastroenterol 2017; 23(29): 5304-5312
- URL: https://www.wjgnet.com/1007-9327/full/v23/i29/5304.htm
- DOI: https://dx.doi.org/10.3748/wjg.v23.i29.5304