From diagnosis to treatment of hepatocellular carcinoma: An epidemic problem for both developed and developing world

Table 1 Barcelona Clinic Liver Cancer staging classification

Tumor status
Stage	PST	Tumor stage	Okuda Stage	Liver function studies
Stage A: early HCC
A1	0	Single	I	No portal hypertension
A2	0	Single	I	Portal hypertension and normal bilirubin
A3	0	Single	I	Portal hypertension and abnormal bilirubin
A4	0	3 tumors < 3 cm	I-II	Child-Pugh A-B
Stage B: idermediate HCC	0	Large multinodular	I-II	Child-Pugh A-B
Stage C: advanced HCC	1-21	Vascular invasion or extrahepatic spread	I-II	Child-Pugh A-B
Stage D: end-stage HCC	3-42	Any	III	Child-Pugh C

¹Stage C, at least one criteria: PST1-2 or vascular invasion/extrahepatic spread;

²Stage D, at least one criteria: PST3-4 or Okuda Stage III/Child-Pugh C. PST: Performance status; Stage A and B, all criteria should be fulfilled.