Myo-inositol reduces β-catenin activation in colitis

Figure 1 Myo-inositol reduces mortality and disease activity indices in IL-10^-/- Px mice. A: Schematic diagram of Px and myo-inositol treatment in IL-10^-/- mice; B: A Kaplan-Meier survival curve shows decreased mortality in IL-10^-/- Px/myo-inositol mice; C: Disease activity indices (DAIs) for IL-10^-/- Px and IL-10^-/- Px/Ins mice. For diarrhea and fecal occult blood (FOB), scores are based on a scale from 0-4, with 0 being normal and 4 being the most severe (Methods). Percent weight change was calculated as weight change relative to the baseline weight at day 1. The composite DAI includes diarrhea and FOB scores, as well as weight change. The bar denotes Px treatment. Data points represent the mean, n = 4 mice in each group. P < 0.05 on day 14.