Case Report
Copyright ©The Author(s) 2017.
World J Gastroenterol. Jul 28, 2017; 23(28): 5246-5252
Published online Jul 28, 2017. doi: 10.3748/wjg.v23.i28.5246
Table 2 Clinical cases of patients with hypothyroidism and hyperammonaemia reported in the literature
YearRef.Clinical presentationThyroid diseaseLiver diseaseEvolution
1992Hitoshi et al[6]Mild dementia, slow speech, hyperreflexia, dysmetria, asterixis with hyperammonaemia.Hypothalamic hypothyroidismCirrhosis and portal hypertensionThyroid hormone replacement improved:
Progression to coma despite lactulose treatment.Hypothyroidism
Hyperammonaemia
NRL disturbances
1999De Nardo et al[7]Hoarseness, fatigue, tongue swelling, myopathy. Hyperammonaemia.Primary hypothyroidismnoneThyroid hormone replacement improved:
Hypothyroidism
Hyperammonaemia
Systemic symptoms and myopathy
2000Thobe et al[8]Coma, hyperammonaemia.Primary hypothyroidismCompensated cirrhosisThyroid hormone replacement improved:
Unresponsive to lactulose.Hypothyroidism
Hyperammonaemia
NRL disturbances
2001Yamamoto et al[9]Dysarthria, disorientation.Primary hypothyroidismDecompensated cirrhosisThyroid hormone replacement improved:
Hypothyroidism
Hyperammonaemia
NRL disturbances
2007Rimar et al[10]Coma, hyperammonaemia. Unresponsive to lactulose.Primary hypothyroidismCompensated cirrhosisThyroid hormone replacement improved:
Hypothyroidism
Hyperammonaemia
NRL disturbances
2007Khairy et al[11]Grade III hepatic encephalopathy.Primary hypothyroidismDecompensated cirrhosisThyroid hormone replacement improved:
Hypothyroidism
NRL disturbances
2012Redkar et al[12]Coma, hyperammonaemia. Unresponsive to lactulose.Primary hypothyroidismDecompensated cirrhosisThyroid hormone replacement improved:
Hypothyroidism
Hyperammonaemia
NRL disturbances