Copyright
©The Author(s) 2017.
World J Gastroenterol. Jul 28, 2017; 23(28): 5246-5252
Published online Jul 28, 2017. doi: 10.3748/wjg.v23.i28.5246
Published online Jul 28, 2017. doi: 10.3748/wjg.v23.i28.5246
Table 2 Clinical cases of patients with hypothyroidism and hyperammonaemia reported in the literature
Year | Ref. | Clinical presentation | Thyroid disease | Liver disease | Evolution |
1992 | Hitoshi et al[6] | Mild dementia, slow speech, hyperreflexia, dysmetria, asterixis with hyperammonaemia. | Hypothalamic hypothyroidism | Cirrhosis and portal hypertension | Thyroid hormone replacement improved: |
Progression to coma despite lactulose treatment. | Hypothyroidism | ||||
Hyperammonaemia | |||||
NRL disturbances | |||||
1999 | De Nardo et al[7] | Hoarseness, fatigue, tongue swelling, myopathy. Hyperammonaemia. | Primary hypothyroidism | none | Thyroid hormone replacement improved: |
Hypothyroidism | |||||
Hyperammonaemia | |||||
Systemic symptoms and myopathy | |||||
2000 | Thobe et al[8] | Coma, hyperammonaemia. | Primary hypothyroidism | Compensated cirrhosis | Thyroid hormone replacement improved: |
Unresponsive to lactulose. | Hypothyroidism | ||||
Hyperammonaemia | |||||
NRL disturbances | |||||
2001 | Yamamoto et al[9] | Dysarthria, disorientation. | Primary hypothyroidism | Decompensated cirrhosis | Thyroid hormone replacement improved: |
Hypothyroidism | |||||
Hyperammonaemia | |||||
NRL disturbances | |||||
2007 | Rimar et al[10] | Coma, hyperammonaemia. Unresponsive to lactulose. | Primary hypothyroidism | Compensated cirrhosis | Thyroid hormone replacement improved: |
Hypothyroidism | |||||
Hyperammonaemia | |||||
NRL disturbances | |||||
2007 | Khairy et al[11] | Grade III hepatic encephalopathy. | Primary hypothyroidism | Decompensated cirrhosis | Thyroid hormone replacement improved: |
Hypothyroidism | |||||
NRL disturbances | |||||
2012 | Redkar et al[12] | Coma, hyperammonaemia. Unresponsive to lactulose. | Primary hypothyroidism | Decompensated cirrhosis | Thyroid hormone replacement improved: |
Hypothyroidism | |||||
Hyperammonaemia | |||||
NRL disturbances |
- Citation: Díaz-Fontenla F, Castillo-Pradillo M, Díaz-Gómez A, Ibañez-Samaniego L, Gancedo P, Guzmán-de-Villoria JA, Fernández-García P, Bañares-Cañizares R, García-Martínez R. Refractory hepatic encephalopathy in a patient with hypothyroidism: Another element in ammonia metabolism. World J Gastroenterol 2017; 23(28): 5246-5252
- URL: https://www.wjgnet.com/1007-9327/full/v23/i28/5246.htm
- DOI: https://dx.doi.org/10.3748/wjg.v23.i28.5246