Sex-influenced association of non-alcoholic fatty liver disease with colorectal adenomatous and hyperplastic polyps

Table 4 Adjusted odds ratios and 95%CIs of clinical variables on the risk of colorectal polyps, adenomatous polyps and hyperplastic polyps according to different-sex groups based on multinomial logistic regression

Polyps	Model A		Model B		Model C
	Male	Female	Male	Female	Male	Female
	OR (95%CI)	OR (95%CI)	OR (95%CI)	OR (95%CI)	OR (95%CI)	OR (95%CI)
Colorectal polyps
NAFLD	1.27 (1.05-1.52)a	1.04 (0.64-1.68)	1.41 (1.16-1.71)a	0.80 (0.49-1.32)	1.40 (1.14-1.71)a	0.78 (0.47-1.28)
Age			1.06 (1.05-1.07)b	1.05 (1.03-1.06)b	1.06 (1.05-1.07)b	1.05 (1.03-1.06)b
Smoking			1.22 (1.02-1.46)a	0.95 (0.66-1.36)	1.23 (1.02-1.50)a	0.88 (0.57-1.36)
Alcohol					0.98 (0.81-1.19)	1.19 (0.81-1.74)
MS					1.07 (0.84-1.37)	1.37 (0.80-2.34)
Adenomatous polyps
NAFLD	1.34 (1.04-1.71)a	0.60 (0.26-1.41)	1.53 (1.19-1.98)a	0.45 (0.19-1.07)	1.53 (1.18-2.00)a	0.44 (0.18-1.04)
Age			1.08 (1.06-1.09)b	1.05 (1.03-1.07)b	1.08 (1.06-1.09)b	1.05 (1.03-1.07)b
Smoking			1.10 (0.86-1.40)	1.24 (0.76-2.02)	1.12 (0.85-1.46)	0.90 (0.50-1.61)
Alcohol					0.97 (0.75-1.25)	1.77 (1.06-2.96)a
MS					0.98 (0.71-1.36)	1.17 (0.53-2.56)
Hyperplastic polyps
NAFLD	1.38 (1.02-1.86)a	1.65 (0.72-3.78)	1.44 (1.06-1.95)a	1.30 (0.56-3.03)	1.42 (1.04-1.95)a	1.18 (0.50-2.78)
Age			1.04 (1.02-1.05)b	1.04 (1.01-1.07)a	1.04 (1.02-1.05)b	1.04 (1.01-1.07)a
Smoking			1.38 (1.03-1.83)a	1.01 (0.49-2.06)	1.38 (1.01-1.88)a	0.71 (0.31-1.65)
Alcohol					1.01 (0.74-1.36)	1.85 (0.92-3.72)
MS					1.02 (0.69-1.52)	2.01 (0.81-4.94)

Model A is univariate analysis; Model B is adjusted for age and smoking; Model C is adjusted for age, smoking, alcohol and MS.

^aP < 0.05,

^bP < 0.001. NAFLD: Non-alcoholic fatty liver disease; MS: Metabolic syndrome.