Sex-dependent difference in the effect of metformin on colorectal cancer-specific mortality of diabetic colorectal cancer patients

Table 2 Multivariate logistic regression analysis for colorectal cancer-specific mortality

	HR	95%CI	P value
Age at diagnosis of ≥ 50 or < 50	0.723	0.312-1.675	0.449
Sex, female or male	0.592	0.357-0.982	0.042
BMI of ≥ 25 or < 25	0.514	0.287-0.919	0.025
Smoking history as yes or no	0.681	0.359-1.291	0.239
Aspirin use as yes or no	0.802	0.455-1.415	0.446
Metformin treatment duration in mo	0.985	0.974-0.997	0.012
Sulfonylurea use as yes or no	1.300	0.798-2.120	0.292
Insulin use as yes or no	1.041	0.511-2.121	0.912
Stage IV or III	8.401	5.285-13.355	< 0.001
Site as rectum or colon	0.823	0.521-1.299	0.403
Pathology	0.801	0.238-2.701	0.721
Diabetes duration	0.968	0.935-1.001	0.059
HbA1C	1.015	1.004-1.027	0.010

BMI: Body mass index; CRC: Colorectal cancer.