Association between CYP24A1 polymorphisms and the risk of colonic polyps and colon cancer in a Chinese population

doi:10.3748/wjg.v23.i28.5179

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 28, 2017; 23(28): 5179-5186
Published online Jul 28, 2017. doi: 10.3748/wjg.v23.i28.5179

Table 3 Associations between the selected single nucleotide polymorphisms and colon cancer, colonic polyp and ulcerative colitis, and odds ratio for the association of each polymorphism with these diseases

Variable (MJ/Mi^a)	MAF^a	HWE P^a	Cases/controls	Genetic model	P for χ² test	Odds ratio for MI/MJ	95%CI
rs4809957 A/G	0.393	0.476	Cancer/1KGeno	G vs A	2.50E-48	0.021	0.009	0.048
			Polyp/1KGeno	G vs A	1.64E-64	0.026	0.014	0.048
			UC/1KGeno	G vs A	1.57E-26	0.008	0.001	0.055
rs6068816 C/T	0.388	0.434	Cancer/1KGeno	T vs C	8.00E-47	32.086	16.238	63.403
			Polyp/1KGeno	T vs C	8.72E-68	48.918	24.888	96.150
			UC/1KGeno	T vs C	3.83E-22	18.260	8.350	39.932
rs6091822 G/T	0.284	0.208	Cancer/1KGeno	T vs G	3.72E-09	2.524	1.844	3.457
			Polyp/1KGeno	T vs G	1.37E-12	2.596	1.984	3.395
			UC/1KGeno	T vs G	0.00001	2.645	1.696	4.125
rs8124792 G/A	0.281	0.616	Cancer/1KGeno	G vs A	1.26E-13	0.083	0.036	0.188
			Polyp/1KGeno	G vs A	2.93E-18	0.086	0.044	0.170
			UC/1KGeno	G vs A	2.58E-07	0.062	0.015	0.256

^aMAF and HWE were calculated among controls only. 1KGeno: Control from 1000 Genomes Project; Cancer: Colon cancer cohort; MI: Minor allele (i.e., less common in controls); MJ: Major allele (i.e., more common in controls); Polyp: Colonic polyp cohort; UC: Ulcerative colitis cohort.

Citation: Chen XQ, Mao JY, Li WB, Li J, Yang H, Qian JM, Li JN. Association between CYP24A1 polymorphisms and the risk of colonic polyps and colon cancer in a Chinese population. World J Gastroenterol 2017; 23(28): 5179-5186
URL: https://www.wjgnet.com/1007-9327/full/v23/i28/5179.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i28.5179