Association between CYP24A1 polymorphisms and the risk of colonic polyps and colon cancer in a Chinese population

doi:10.3748/wjg.v23.i28.5179

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Jul 28, 2017; 23(28): 5179-5186
Published online Jul 28, 2017. doi: 10.3748/wjg.v23.i28.5179

Table 2 Association between the selected single nucleotide polymorphisms and risks of colon cancer, polyp and ulcerative colitis

Variable (MJ/MI)	Cases/controls	Genetic model	P for Fisher's test
rs4809957 A/G	Cancer/1KGeno	AG + GG vs AA	2.20E-16
		G vs A	2.20E-16
		GG vs AG + AA	2.20E-16
	Polyp/1KGeno	AG + GG vs AA	2.20E-16
		G vs A	2.20E-16
		GG vs AG + AA	2.20E-16
	UC/1KGeno	AG + GG vs AA	2.20E-16
		G vs A	2.20E-16
		GG vs AG + AA	9.37E-09
	Cancer/Polyp	AG + GG vs AA	0.7998
		G vs A	0.8036
		GG vs AG + AA	1.0000
	Cancer/UC	AG + GG vs AA	0.4362
		G vs A	0.4424
		GG vs AG + AA	1.0000
	Polyp/UC	AG + GG vs AA	0.3011
		G vs A	0.3096
		GG vs AG + AA	1.0000
rs6068816 C/T	Cancer/1KGeno	CT + TT vs CC	2.20E-16
		T vs C	2.20E-16
		TT vs CT + CC	2.20E-16
	Polyp/1KGeno	CT + TT vs CC	2.20E-16
		T vs C	2.20E-16
		TT vs CT + CC	2.20E-16
	UC/1KGeno	CT + TT vs CC	2.29E-09
		T vs C	2.20E-16
		TT vs CT + CC	2.20E-16
	Cancer/Polyp	CT + TT vs CC	1.0000
		T vs C	0.4635
		TT vs CT + CC	0.4546
	Cancer/UC	CT + TT vs CC	1.0000
		T vs C	0.2786
		TT vs CT + CC	0.2658
	Polyp/UC	CT + TT vs CC	1.0000
		T vs C	0.06703
		TT vs CT + CC	0.06164
rs6091822 G/T	Cancer/1KGeno	GT + TT vs GG	2.20E-16
		T vs G	1.06E-08
		TT vs GT + GG	0.000472
	Polyp/1KGeno	GT + TT vs GG	2.20E-16
		T vs G	4.06E-12
		TT vs GT + GG	0.001364
	UC/1KGeno	GT + TT vs GG	1.32E-13
		T vs G	2.40E-05
		TT vs GT + GG	0.2411
	Cancer/Polyp	GT + TT vs GG	1.0000
		T vs G	0.9258
		TT vs GT + GG	0.5180
	Cancer/UC	GT + TT vs GG	1.0000
		T vs G	0.8971
		TT vs GT + GG	0.3094
	Polyp/UC	GT + TT vs GG	1.0000
		T vs G	1.0000
		TT vs GT + GG	0.5456
rs8124792 G/A	Cancer/1KGeno	GA + AA vs GG	2.20E-16
		A vs G	2.20E-16
		AA vs GA + GG	0.000758
	Polyp/1KGeno	GA + AA vs GG	2.20E-16
		A vs G	2.20E-16
		AA vs GA + GG	4.75E-05
	UC/1KGeno	GA + AA vs GG	4.90E-09
		A vs G	2.91E-09
		AA vs GA + GG	0.06359
	Cancer/Polyp	GA + AA vs GG	1.0000
		A vs G	1.0000
		AA vs GA + GG	1.0000
	Cancer/UC	GA + AA vs GG	1.0000
		A vs G	1.0000
		AA vs GA + GG	1.0000
	Polyp/UC	GA + AA vs GG	1.0000
		A vs G	1.0000
		AA vs GA + GG	1.0000

1KGeno: Control from 1000 Genomes Project; Cancer: Colon cancer cohort; MI: Minor allele (i.e., less common in controls); MJ: Major allele (i.e., more common in controls); Polyp: Colonic polyp cohort; UC: Ulcerative colitis cohort.

Citation: Chen XQ, Mao JY, Li WB, Li J, Yang H, Qian JM, Li JN. Association between CYP24A1 polymorphisms and the risk of colonic polyps and colon cancer in a Chinese population. World J Gastroenterol 2017; 23(28): 5179-5186
URL: https://www.wjgnet.com/1007-9327/full/v23/i28/5179.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i28.5179