Copyright
©The Author(s) 2017.
World J Gastroenterol. Jul 28, 2017; 23(28): 5051-5067
Published online Jul 28, 2017. doi: 10.3748/wjg.v23.i28.5051
Published online Jul 28, 2017. doi: 10.3748/wjg.v23.i28.5051
Table 4 Summary of molecular biomarkers predicting malignant progression
Biomarker | Phase | Sample size | End-point |
Biomarker panels | |||
8-gene methylation panel | 3 | 195 | High grade dysplasia/adenocarcinoma |
DNA content abnormalities and loss of heterozygosity | 4 | 243 | Adenocarcinoma |
Expert low grade dysplasia, aneuploidy, Aspergillus oryzae lectin | 3 | 380 | Adenocarcinoma |
DNA content abnormalities | |||
Aneupolidy/tetraploidy | 4 | 322 | Adenocarcinoma |
Tumour suppressor loci | |||
p53 loss of heterozygosity | 4 | 256 | Adenocarcinoma |
p53 staining | 4 | 48 | High grade dysplasia/adenocarcinoma |
Epigenetics | |||
P16 methylation | 3 | 53 | HD/adenocarcinoma |
Proliferation | |||
Mcm2 | 3 | 27 | Adenocarcinoma |
Clonal diversity | |||
Clonal diversity measures | 4 | 239 | Adenocarcinoma |
Cell cycle markers | |||
Cyclin A | 3 | 48 | High grade dysplasia/adenocarcinoma |
Cyclin D1 | 3 | 307 | Adenocarcinoma |
Serum biomarkers | |||
Leukocyte telomere length | 4 | 300 | Adenocarcinoma |
Selenoprotein P | 4 | 361 | Adenocarcinoma |
- Citation: Amadi C, Gatenby P. Barrett’s oesophagus: Current controversies. World J Gastroenterol 2017; 23(28): 5051-5067
- URL: https://www.wjgnet.com/1007-9327/full/v23/i28/5051.htm
- DOI: https://dx.doi.org/10.3748/wjg.v23.i28.5051