Human liver chimeric mouse model based on diphtheria toxin-induced liver injury

Figure 4 Human albumin plasma concentration in Alb-cre/DTR/SCID-beige mice after adult hepatocyte transplantation. A: Schematic of liver humanization. Two days after the intraperitoneal injection of DT, serum was collected for ALT assay. Human hepatocytes were transplanted into these mice on the same day; B: Serum levels of human albumin are shown for ADSB mice (n = 5) on day 7, 14, 21 and 28 after hepatocyte transplantation as detected by enzyme-linked immunosorbent assay. Results are mean ± SEM (n ≥ 3); ^bP < 0.01. ADSB: Triple-crossed albumin (Alb)-cre transgenic mice, inducible diphtheria toxin receptor (DTR) transgenic mice and severe combined immune deficient-beige mice; ALT: Alanine aminotransferase; DT: Diphtheria toxin.