Human liver chimeric mouse model based on diphtheria toxin-induced liver injury

Figure 3 Body weight and alanine aminotransferase analysis after diphtheria toxin injection. ADSB mice (filled circle) and non-transgenic mice (open circle) were injected with 2.5 ng/g bodyweight DT. A: The bodyweight change ratio in the two groups of mice after injection of DT; B: Analysis of serum ALT activity in the mice. Data are shown as the mean of each group, and error bars represent SD (n = 3); ^aP < 0.05, ^bP < 0.01, ^eP < 0.001. ADSB: Triple-crossed albumin (Alb)-cre transgenic mice, inducible diphtheria toxin receptor (DTR) transgenic mice and severe combined immune deficient-beige mice; ALT: Alanine aminotransferase; DT: Diphtheria toxin.