Human liver chimeric mouse model based on diphtheria toxin-induced liver injury

Figure 2 Histological analysis of liver injury. Two days after DT treatment, liver sections from non-transgenic mice and ADSB mice were stained with H and E. A: The liver from non-transgenic mice (C57BL/6); B: The liver from ADSB mouse; C: A representative liver section from non-transgenic mice showing normal histological appearance; D: A representative liver section from ADSB mice showing liver injury. ADSB: Triple-crossed albumin (Alb)-cre transgenic mice, inducible diphtheria toxin receptor (DTR) transgenic mice and severe combined immune deficient-beige mice; DT: Diphtheria toxin; H and E: Hematoxylin and eosin.