Genetic association and epistatic interaction of the interleukin-10 signaling pathway in pediatric inflammatory bowel disease

Figure 2 Gene-gene interaction between IL-10 and IL10RA, IL10RB and HO1 in pediatric inflammatory bowel disease. A: Graphic depiction of epistatic interaction between the IL-10 SNP rs3024496 and the IL10RA rs3135932. Four interaction models for rs3024496 and rs3135932 are shown. The additive-additive and additive-dominant models are both weak (Bp = 0.433 and 0.426 respectively), and the other two models are not observed (Bp = 1, no color); B: Graphical depiction of epistatic interaction between the HO1 rs2071746 and the IL10RB rs2834167. Four interaction models for rs3024496 and rs3135932 are shown. Only the additive-dominant model is significant (Bp = 0.039), and the other three models are not observed (Bp = 1, no color). The levels of Bp values are shown in the bar as shades of blue color from none (Bp = 1) to high (Bp = 0.001). Bp: Bonferroni P value; SNPs: Single nucleotide polymorphisms.