High expression of anti-apoptotic protein Bcl-2 is a good prognostic factor in colorectal cancer: Result of a meta-analysis

Table 2 Subgroup analysis of pooled hazard ratios for colorectal cancer patients with overexpressed Bcl-2

Stratified analysis	No. of studies	No. of patients	Pooled HR (95%CI)	P value	Heterogeneity
					I² (%)	P value
No. of patients
≥ 100	22	6274	0.684 (0.54-0.866)	0.002	75.9	0.000
< 100	12	712	0.693 (0.389-1.235)	0.214	85.8	0.000
Study location
Asia	7	777	1.021 (0.488-2.136)	0.955	88.2	0.000
Europe and America	26	6143	0.691 (0.553-0.864)	0.001	73.9	0.000
Treatment before surgery
Yes	7	2056	0.772 (0.55-0.947)	0.394	73.8	0.001
No	18	2615	0.696 (0.502-0.964)	0.029	79.9	0.000
Quality score
≥ 7	18	2471	0.678 (0.499-0.92)	0.013	71.8	0.000
< 7	16	4515	0.708 (0.503-0.996)	0.047	84.9	0.000