Genetic polymorphisms predict response to anti-tumor necrosis factor treatment in Crohn’s disease

Table 6 Multivariable logistic regression models predicting anti-tumor necrosis factor treatment failure

Model	Variable	Class	Estimate	Global P value	OR (95%CI)
a	FAS ligand rs763110 (TC + TT grouped)	CC	1.460	0.009	4.30 (1.45-12.80)
		TC+TT	0
	Montreal behavior (B)	B1	-0.083	NS	0.92 (0.21-3.96)
		B2	1.158		3.18 (0.89-11.34)
		B3	0
	Montreal behavior (p) perianal	No	0.964	NS	2.62 (0.68-10.09)
		Yes	0
b	TNF gene (-308) rs1800629 (AA+GA grouped)	AA+GA	1.056	0.049	2.88 (1.01-8.22)
		GG	0
	Montreal Behavior (B)	B1	-0.153	NS	0.86 (0.20-3.59)
		B2	0.826		2.28 (0.68-7.61)
		B3	0
	Montreal Behavior (p) perianal	No	1.213	NS	3.36 (0.87-12.93)
		Yes	0
c	FAS ligand (CC genotype) and TNF gene -308 (AA or GA genotype) combined	CC and AA or GA	1.560	0.015	4.76 (1.35-16.77)
		Other	0
	Montreal behavior (B)	B1	-0.022	NS	0.98 (0.23-4.22)
		B2	0.950		2.59 (0.73-9.17)
		B3	0
	Montreal behavior (p) perianal	No	0.970	NS	2.64 (0.69-10.10)
		Yes	0