Genetic polymorphisms predict response to anti-tumor necrosis factor treatment in Crohn’s disease

Table 5 Univariable logistic regression data regarding factors associated with anti-tumor necrosis factor treatment failure

Covariate	P value
Demographic variables
Gender	NS
Race	NS
Montreal Classification
Age of onset (A) Montreal	NS
Location (L) Montreal	NS
Location (L4) upper GI Montreal	NS
Behavior (B) Montreal	0.131
Behavior (p) perianal Montreal	0.091
SNP variables
ATG16L1 rs10210302	NS
ATG16L1 rs2241880	NS
FAS Ligand rs763110	0.0571
FAS Ligand rs763110 (TC + TT grouped)	0.021
IBD5 rs2522057	NS
FCGR 3A rs396991	NS
TNF gene (-308) rs1800629	0.131
TNF gene (-308) rs1800629 (AA + GA grouped)	0.0991
TNF gene(-238) rs361525	NS

¹Covariates included in the subsequent multivariable analysis. TNF: Tumor necrosis factor; SNPs: Single nucleotide polymorphisms.