Genetic polymorphisms predict response to anti-tumor necrosis factor treatment in Crohn’s disease

doi:10.3748/wjg.v23.i27.4958

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 21, 2017; 23(27): 4958-4967
Published online Jul 21, 2017. doi: 10.3748/wjg.v23.i27.4958

Table 3 Single nucleotide polymorphisms tested with genotype and allele distribution for entire patients group n (%)

				Genotype distribution		Allele distribution
SNP	Location relative to gene (Chromosome number)	Nucleotide change	Assay successful	Genotype	Frequency	Allele	Frequency
ATG16L1 rs10210302	2 kb upstream (2)	C/T	119 (98)	CC	25 (21.0)	Total	238
				TC	57 (47.9)	C	107 (45.0)
				TT	37 (31.1)	T	131 (55.0)
ATG16L1 rs2241880	Thr300Ala (2)	A/G	120 (99)	AA	27 (22.5)	Total	240
				GA	57 (47.5)	A	111 (46.3)
				GG	36 (30.0)	G	129 (53.7)
FAS ligand rs763110	-843 (1)	C/T	115 (95)	CC	42 (36.5)	Total	230
				TC	54 (47.0)	C	138 (60.0)
				TT	19 (16.5)	T	92 (40.0)
IBD5 rs2522057	Intergenic region (5)	C/G	120 (99)	CC	35 (29.2)	Total	240
				GC	49 (40.8)	C	119 (49.6)
				GG	36 (30.0)	G	121 (50.4)
FCGR 3A rs396991	Phe175Val (1)	C/G	120 (99)	AA	70 (58.3)	Total	240
				AC	33 (27.5)	A	173 (72.1)
				CC	17 (14.2)	C	67 (27.9)
TNF gene (-308) rs1800629	promotor region (6)	A/G	119 (98)	AA	4 (3.4)	Total	238
				GA	31 (26.1)	A	39 (19.6)
				GG	84 (70.6)	G	199 (80.4)
TNF gene (-238) rs361525	promotor region (6)	A/G	120 (99)	AA	2 (1.7)	Total	240
				GA	15 (12.5)	A	19 (7.9)
				GG	103 (85.8)	G	221 (92.1)

TNF: Tumor necrosis factor; SNPs: Single nucleotide polymorphisms.

Citation: Netz U, Carter JV, Eichenberger MR, Dryden GW, Pan J, Rai SN, Galandiuk S. Genetic polymorphisms predict response to anti-tumor necrosis factor treatment in Crohn’s disease. World J Gastroenterol 2017; 23(27): 4958-4967
URL: https://www.wjgnet.com/1007-9327/full/v23/i27/4958.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i27.4958