Genetic association and epistatic interaction of the interleukin-10 signaling pathway in pediatric inflammatory bowel disease

Table 8 Epistatic interaction of IL10RB and HO1 with IL-10 (three single nucleotide polymorphisms), IL10RA, or STAT3

	Epistatic model	IL-10 rs1800872, P = 0.71; Bp = 1	IL-10 rs3024498, P = 0.616; Bp = 21	IL-10 rs3024496, P = 0.022; Bp = 0.0226	IL10RA rs3135932, P = 0.16; Bp = 1	STAT3 rs744166, P = 0.352; Bp = 1
aa IL10RB rs2834167 and HO1 rs2071746	aaa	P = 0.029;	P = 0.545;	P = 0.255;	P = 0.023;	P = 0.049;
		Bp = 1	Bp = 1	Bp = 1	Bp = 0.820	Bp = 1
	aad	P = 0.127;	P = 0.240;	P = 0.928;	P = 0.193;	P = 0.554;
		Bp = 1	Bp = 1	Bp = 1	Bp = 1	Bp = 1
ad IL10RB rs2834167 and HO1 rs2071746	ada	P = 0.394;	P = 0.824;	P = 0.242;	P = 0.444;	P = 0.436;
		Bp = 1	Bp = 1	Bp = 1	Bp = 1	Bp = 1
	add	P = 0.976;	P = 0.406;	P = 0.327;	P = 0.644;	P = 0.649;
		Bp = 1	Bp = 1	Bp = 1	Bp = 1	Bp = 1
da IL10RB rs2834167 and HO1 rs2071746	daa	P = 0.00015;	P = 0.489;	P = 0.047;	P = 0.008;	P = 0.014;
		Bp = 0.005	Bp = 1	Bp = 1	Bp = 0.287	Bp = 0.491
	dad	P = 0.072;	P = 0.140;	P = 0.388;	P = 0.205;	P = 0.977;
		Bp = 1	Bp = 1	Bp = 1	Bp = 1	Bp = 1
dd IL10RB rs2834167 and HO1 rs2071746	dda	P = 0.199;	P = 0.808;	P = 0.568;	P = 0.766;	P = 0.4731;
		Bp = 1	Bp = 1	Bp = 1	Bp = 1	Bp = 1
	ddd	P = 0.694;	P = 0.958;	P = 0.007;	P = 0.181;	P = 0.057;
		Bp = 1	Bp = 1	Bp = 0.242	Bp = 1	Bp = 1

All four interaction models (aa, ad, da and dd) of IL10RB and HO1 were used for this analysis, as well as both of the interaction models (a and d) of each gene studied. A total of eight interaction models for three SNPs are listed. The dad model of IL10RB and HO1 with the IL-10 rs1800872 is significant (Bp = 0.005). The daa models for IL10RB and HO1 with either IL10RA or STAT3 is weak (Bp = 0.287 and Bp = 0.491 respectively). Bp: Bonferroni P value.