Genetic association and epistatic interaction of the interleukin-10 signaling pathway in pediatric inflammatory bowel disease

Table 7 Epistatic interaction among the two IL-10 single nucleotide polymorphisms, rs1800872 and rs3024496, and IL10RA, IL10RB, STAT3, or HO1

	Epistatic model	IL10RA rs3135932, P = 0.16; Bp = 1	IL10RB rs2834167, P = 0.203; Bp = 1	STAT3 rs744166, P = 0.352; Bp = 1	HO1 rs2071746, P = 0.634; Bp = 1
Two IL-10 SNPs: rs1800872 and rs3024496 aa: P = 0.0002; Bp = 0.003	aaa	P = 0.003; Bp = 0.099	P = 0.080; Bp = 1	P = 0.175; Bp = 1	P = 0.216; Bp = 1
	aad	P = 0.130; Bp = 1	P = 0.340; Bp = 1	P = 0.920; Bp = 1	P = 0.140; Bp = 1

The additive-additive (aa) interaction model for the two IL-10 SNPs (rs1800872 and rs3024496) from Figure 1 was chosen for further analysis, in order to study the interaction of these two IL-10 SNPs with SNPs of four other genes. The two interaction models, aaa and aad, were for the two IL-10 SNPs and SNPs from each of the four genes. A significant P value (P = 0.003) was observed only with the IL10RA SNP (rs3135932). Bp: Bonferroni P value; SNPs: Single nucleotide polymorphisms.