Genetic association and epistatic interaction of the interleukin-10 signaling pathway in pediatric inflammatory bowel disease

Table 5 Epistatic interaction between two single nucleotide polymorphisms in three IL-10 single nucleotide polymorphisms studied

	Epistatic model	rs3024496, P = 0.022, Bp = 0.0226	rs3024498, P = 0.616; Bp = 1
rs1800872, P = 0.71; Bp = 1	aa	P = 0.00015; Bp = 0.003	P = 0.638; Bp = 1
	ad	P = 0.057; Bp = 1	P = 0.605; Bp = 1
	da	P = 0.010; Bp = 0.216	P = 0.977; Bp = 1
	dd	P = 0.239; Bp = 1	P = 0.049; Bp = 1
rs3024496, P = 0.022, Bp = 0.0226	aa		P = 0.371; Bp = 1
	ad		P = 0.222; Bp = 1
	da		P = 0.167; Bp = 1
	dd		P = 0.584; Bp = 1

The P and Bp values for each SNP are shown next to each SNP; the P and Bp values for each of two SNP interactions are shown in the 3^rd and 4^th column. In the 2^nd column (epistatic model), a: Additive; d: Dominant. For a two SNP interaction, four different types of interactions may occur: additive-additive (aa), additive-dominant (ad), dominant-additive (da), and dominant-dominant (dd). Bp: Bonferroni P value; SNP: Single nucleotide polymorphism.