Genetic association and epistatic interaction of the interleukin-10 signaling pathway in pediatric inflammatory bowel disease

Table 4 Genetic association of IL-10, IL10RA, IL10RB, STAT3 and HO1 genes with pediatric inflammatory bowel disease

Gene	SNP ID	Genotype	Disease, n	Control, n	OR	95%CI	P value
IL-10	rs1800872	CC	89	78	0.863	0.564-1.313	0.71
		CA	68	50
		AA	2	1
		C allele	246	206
		A allele	72	52
	rs3024498	CC	86	77	0.830	0.552-1.244	0.616
		CT	65	47
		TT	8	5
		C allele	237	201
		T allele	81	57
	rs3024496	AA	57	27	1.487	1.055-2.099	0.022
		AG	69	69
		GG	33	33
		A allele	183	123
		G allele	185	135
IL10RA	rs3135932	AA	108	85	0.925	0.595-1.433	0.160
		AG	39	40
		GG	12	4
		A allele	255	210
		G allele	63	48
IL10RB	rs2834167	AA	91	64	1.318	0.884-1.968	0.203
		AG	66	60
		GG	2	5
		A allele	248	188
		G allele	70	70
STAT3	rs744166	GG	64	49	0.943	0.662-1.340	0.352
		AG	66	63
		AA	29	17
		A allele	194	161
		G allele	124	97
HO1	rs2071746	AA	32	30	0.957	0.680-1.348	0.634
		AT	96	71
		TT	31	28
		A allele	158	131
		T allele	160	127

SNP: Single nucleotide polymorphism.