Helicobacter pylori vacA genotype is a predominant determinant of immune response to Helicobacter pylori CagA

Figure 3 Inflammatory potential based on CagA-IgG in gastric mucosa ex vivo and in vitro using AGS cells. A: IL-8 mRNA expression was evaluated in antrum mucosa from patients with chronic gastritis [CG, AG, IM, without peptic ulcer disease (PUD) and gastric cancer (GC)] with (n = 23) and without CagA seropositivity (n = 48); B: IL-8 expression in antrum mucosa from patients with PUD and gastric cancer (n = 4 for CagA-IgG+ and n = 6 CagA-IgG-); C: IL-8 mRNA; D: IL-8 protein expression in supernatant are shown for subgroups dependent on cagA, cagA mRNA and anti-CagA-IgG status in vitro using co-culturing of Helicobacter pylori strains from patients with AGS cells.