Fibrinogen deficiency suppresses the development of early and delayed radiation enteropathy

Figure 5 Intestinal smooth muscle cell proliferation, collagen deposition and TGF-β immunoreactivity in Fib^+/- and Fib^-/- mice observed at 2 wk and 26 wk after localized irradiation. A: Comparative assessment of intestinal smooth muscle cell proliferation between Fib^+/- (n = 13) and Fib^-/- (n = 13) mice at 2 wk and Fib^+/- (n = 19) and Fib^-/- (n = 12) mice at 26 wk by measuring PCNA immunoreactivity; B and C: Representative photomicrographs showing PCNA immunoreactivity in Fib^+/- and Fib^-/-, respectively, at 2 wk after exposure; D: Comparative assessment of collagen deposition between Fib^+/- (n = 11) and Fib^-/- (n = 14) mice at 2 wk and Fib^+/- (n = 17) and Fib^-/- (n = 10) mice at 26 wk; E and F: Representative photomicrographs showing Collagen deposition by Trichrome staining in Fib^+/- and Fib^-/-, respectively, at 2 wk after exposure; G: Comparative assessment of TGF-β immunoreactivity between Fib^+/- (n = 13) and Fib^-/- (n = 13) mice at 2 wk and Fib^+/- (n = 21) and Fib^-/- (n = 12) mice at 26 wk; H and I: Representative photomicrographs showing TGF-β immunoreactivity in Fib^+/- and Fib^-/-, respectively, at 2 wk after exposure.