Fibrinogen deficiency suppresses the development of early and delayed radiation enteropathy

Figure 4 Intestinal inflammation and intestinal mucosal injury in Fib^+/- and Fib^-/- mice observed at 2 wk and 26 wk after localized irradiation. A: Comparative assessment of intestinal inflammation between Fib^+/- (n = 13) and Fib^-/- (n = 14) mice at 2 wk and Fib^+/- (n = 28) and Fib^-/- (n = 13) mice at 26 wk by measuring myeloperoxidase activity; B and C: Representative photomicrographs showing myeloperoxidase positive cells in Fib^+/- and Fib^-/-, respectively, at 2 wk after exposure; D: Comparative assessment of intestinal mucosal injury between Fib^+/- (n = 15) and Fib^-/- (n = 14) mice at 2 wk and Fib^+/- (n = 28) and Fib^-/- (n = 11) mice at 26 wk; E and F: Representative photomicrographs showing difference in mucosal surface area by H&E staining in Fib^+/- and Fib^-/-, respectively, at 2 wk after exposure.