Non-invasive assessment of liver fibrosis using two-dimensional shear wave elastography in patients with autoimmune liver diseases

Table 4 Performance characteristics of two-dimensional shear wave elastography for staging liver fibrosis in patients with autoimmune liver diseases

	Cutoff, kPa	Se, % (95%CI)	Sp, % (95%CI)	PPV, % (95%CI)	NPV, % (95%CI)	LR+, ratio (95%CI)	LR-, ratio (95%CI)
≥ F2	9.71	81.7 (71.6-89.4)	81.3 (63.6-92.8)	91.8 (83.0-96.9)	63.4 (46.9-77.9)	4.4 (3.6-5.3)	0.23 (0.10-0.5)
	7.22	93.9 (86.3-98.0)	40.6 (23.7-59.4)	80.2 (70.8-87.6)	72.2 (46.5-90.3)	1.6 (1.0-2.4)	0.15 (0.06-0.4)
	7.13	93.9 (86.3-98.0)	37.5 (21.1-56.3)	79.4 (70.0-86.9)	70.6 (44.0-89.7)	1.5 (1.0-2.4)	0.16 (0.07-0.4)
≥ F3	13.21	83.0 (69.2-92.4)	74.6 (62.5-84.5)	69.6 (55.8-81.3)	86.2 (74.6-93.9)	3.3 (2.7-4.0)	0.23 (0.1-0.5)
	9.12	95.7 (85.5-9.5)	52.2 (39.7-64.6)	58.4 (46.6-69.6)	94.6 (81.5-99.4)	2.0 (1.6-2.5)	0.08 (0.02-0.3)
	8.73	97.9 (88.7-99.9)	49.3 (36.8-61.8)	57.5 (45.9-68.5)	97.1 (84.7-99.9)	1.9 (1.5-2.5)	0.04 (0.01-0.3)
F4	16.31	87.0 (66.4-97.2)	80.2 (70.6-87.8)	52.6 (35.6-69.2)	96.1 (88.9-99.2)	4.4 (3.6-5.3)	0.16 (0.05-0.5)
	11.72	95.7 (78.1-99.9)	57.1 (46.3-67.5)	36.1 (24.2-49.4)	98.1 (89.8-100.0)	2.2 (1.8-2.7)	0.08 (0.01-0.5)
	10.43	95.7 (78.1-99.9)	48.4 (37.7-59.1)	31.9 (21.2-44.2)	97.8 (88.2-99.9)	1.9 (1.5-2.3)	0.09 (0.01-0.6)

¹Cut-off values in patients with autoimmune liver diseases;

²Cut-off values in patients with chronic hepatitis B;

³Cut-off values in patients with chronic hepatitis C. Se: Sensitivity; Sp: Specificity; PPV: Positive predictive value; NPV: Negative predictive value; LR+: Positive likelihood ratio; LR-: Negative likelihood ratio.