Divergent expression of bacterial wall sensing Toll-like receptors 2 and 4 in colorectal cancer

Table 5 5-year cancer-specific survival in percent (number of cases) vs intensity of staining in the tumour bulk, invasive front, and lymph node metastases n (%)

		Intensity of staining	Whole colon	P value1	Proximal colon	P valu1	Distal colon and rectum	P value1
TLR2	Tumour bulk	Weak	14 (63.6)	0.43	4 (66.7)	0.65	9 (60.0)	0.33
		Strong	71 (74.7)		29 (74.4)		42 (75.0)
	Invasive front	Weak	14 (73.7)	> 0.9	6 (66.7)	0.68	8 (80.0)	0.71
		Strong	70 (72.2)		27 (75.0)		42 (70.0)
	Lymph node	Weak	9 (50.0)	0.55	3 (37.5)	> 0.9	6 (60.0)	0.26
		Strong	10 (40.0)		3 (42.9)		6 (35.3)
TLR4	Tumour bulk	Weak	25 (65.8)	0.27	7 (63.6)	0.45	18 (66.7)	0.59
		Strong	60 (75.9)		26 (76.5)		33 (75.0)
	Invasive front	Weak	17 (63.0)	0.33	5 (45.5)	0.044	12 (75.0)	> 0.9
		Strong	67 (75.3)		28 (82.4)		38 (70.4)
	Lymph node	Weak	2 (25.0)	0.27	0 (0.0)	0.23	2 (40.0)	> 0.9
		Strong	17 (48.6)		6 (50.0)		10 (45.5)

¹χ² test/Fisher’s exact test. N values vary due to missing samples; One case with multiple tumours excluded from location-based analysis; Weak intensity < 2 and strong intensity ≥ 2.