Divergent expression of bacterial wall sensing Toll-like receptors 2 and 4 in colorectal cancer

Table 3 Mean intensities and histoscores of immunostaining

	TLR2 intensity, mean ± SD	P value	TLR2 histoscore, mean ± SD	P value	TLR4 intensity, mean ± SD	P value	TLR4 histoscore, mean ± SD	P value
Invasive front	2.3 ± 0.6	< 0.001	224 ± 67	< 0.001	2.2 ± 0.6	< 0.001	223 ± 66	0.024
Normal mucosa	1.4 ± 0.7		129 ± 72		2.6 ± 0.6		243 ± 77
Invasive front	2.2 ± 0.7	0.006	210 ± 77	0.054	2.2 ± 0.6	0.060	216 ± 68	0.048
Lymph node	1.8 ± 0.7		180 ± 72		2.4 ± 0.7		241 ± 70
Tumour bulk	2.3 ± 0.6	< 0.001	224 ± 65	< 0.001	2.0 ± 0.7	< 0.001	197 ± 73	< 0.001
Normal mucosa	1.4 ± 0.7		129 ± 72		2.6 ± 0.6		244 ± 78
Tumour bulk	2.2 ± 0.6	0.007	216 ± 65	0.011	2.0 ± 0.6	0.001	194 ± 69	0.001
Lymph node	1.8 ± 0.7		180 ± 72		2.4 ± 0.7		241 ± 70
Lymph node	1.8 ± 0.7	0.011	179 ± 70	0.003	2.4 ± 0.7	0.017	238 ± 70	0.40
Normal mucosa	1.4 ± 0.7		127 ± 71		2.7 ± 0.5		251 ± 72
Invasive front	2.3 ± 0.6	0.55	225 ± 66	> 0.9	2.3 ± 0.6	< 0.001	223 ± 66	< 0.001
Tumour bulk	2.3 ± 0.6		225 ± 64		2.0 ± 0.7		197 ± 73

Mean values vary due to missing samples. TLR: Toll-like receptor.