Predictors of esophageal varices and first variceal bleeding in liver cirrhosis patients

Table 2 Association of non-invasive markers with presence of esophageal varices in liver cirrhosis

Non-invasive markers	Left panel: Unadjusted models		Right panel: Multivariable-adjusted models2
	OR (95%CI)1	P1 vaule	OR (95%CI)	P vaule
FIB-4	1.18 (1.01-1.38)	0.032	1.57 (1.15-2.14)	0.005
Fibrosis index	1.25 (0.90-1.74)	0.177
King score	1.00 (0.99-1.01)	0.501
APRI	1.01 (0.90-1.14)	0.866
PL/SD	1.00 (0.99-1.00)	0.078
AST/ALT	1.15 (0.84-1.57)	0.395
MELD	1.11 (1.01-1.22)	0.026

¹Odds ratios (OR: Esophageal varices vs no esophageal varices), 95%CI and P values from binary logistic regression.

²Models adjusted for age, sex, etiology of liver cirrhosis, CTP, VPT, hemoglobin, creatinine, AST, ALT, GGT, gama globulin, INR, albumin, FIB 4, fibrosis index, king score, APRI, PL/SD, AST/ALT and MELD. All variables were entered in a backward stepwise elimination procedure with a p-value to exit set at > 0.10. Empty cells refer to the variables excluded from the multivariable-adjusted logistic regression models. AST/ALT: Aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio; APRI: AST to platelet ratio index; FIB-4: Fibrosis-4-index; MELD: Model for end-stage liver disease; PC/SD: Platelet count to spleen diameter.