Helicobacter pylori vacA genotype is a predominant determinant of immune response to Helicobacter pylori CagA

doi:10.3748/wjg.v23.i26.4712

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 14, 2017; 23(26): 4712-4723
Published online Jul 14, 2017. doi: 10.3748/wjg.v23.i26.4712

Table 3 Validation of CagA expression and cellular translocation in AGS cells

	Strain characterization				*In vitro*
ID	cagA DNA	cagA RNA	CagA-IgG	*vacA*	H.pylori CagA	*AGS + H.pylori* CagA**	*AGS + H.pylori* p-CagA**
BCM300	+	+		s1m1	+	+	+
117	+	+	+	s1m1	+	+	+
6	+	+	-	s1m1	+	+	+
255	+	+	-	s1m1	+	+	+
13/1	+	+	+	s1m1	+	+	-
46	+	+	-	s1m1	+	+	-
89	+	+	-	s1m2	+	+	-
424	+	+	+	s1m2	-	-	-
21	+	-	-	s1m1	-	-	-
321	+	+	-	s2m2	-	-	-
374	+	+	-	s2m2	-	-	-
342	+	-	-	s2m2	-	-	-
314	-	-	-	s1m2	-	-	-
450	-	-	-	s1m2	-	-	-

AGS cells co-cultivated in similar conditions without Helicobacter pylori were considered as negative control. Strains were characterized based on cagA DNA/RNA/cagA-IgG seropositivity of the host and vacA polymorphism. “+”: positive and “-“: negative expression. p-CagA and CagA: Phosphorylated p-CagA and total CagA protein expression in vitro.

Citation: Link A, Langner C, Schirrmeister W, Habendorf W, Weigt J, Venerito M, Tammer I, Schlüter D, Schlaermann P, Meyer TF, Wex T, Malfertheiner P. Helicobacter pylori vacA genotype is a predominant determinant of immune response to Helicobacter pylori CagA. World J Gastroenterol 2017; 23(26): 4712-4723
URL: https://www.wjgnet.com/1007-9327/full/v23/i26/4712.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i26.4712