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©The Author(s) 2017.
World J Gastroenterol. Jul 14, 2017; 23(26): 4712-4723
Published online Jul 14, 2017. doi: 10.3748/wjg.v23.i26.4712
Published online Jul 14, 2017. doi: 10.3748/wjg.v23.i26.4712
Table 2 Characteristics of Helicobacter pylori strains in CagA IgG dependent status of the host n (%)
Total | H. pylori +CagA-IgG- | H. pylori +CagA-IgG+ | P value | |
Total | 99 | 69 (69.7) | 30 (30.3) | |
cagA gene1 | NS | |||
Positive | 93 | 63 (91.3) | 30 (100) | |
Negative | 6 | 6 (8.7) | 0 | |
cagA mRNA2 | 87 | 60 | 27 | < 0.0001 |
Positive | 61 | 34 (56.7) | 27 (100) | |
Negative | 26 | 26 (43.3) | 0 (0) | |
EPIYA motifs | NS | |||
Negative | 5 | 5 (7.2) | 0 | |
AB | 4 | 2 (2.9) | 2 (6.7) | |
ABC | 33 | 21 (30.4) | 12 (40) | |
ABCC | 7 | 6 (8.7) | 1 (3.3) | |
ABCCC | 2 | 1 (14.5) | 1 (3.3) | |
Mixed | 48 | 34 (49.3) | 14 (46.7) | |
VacA-IgG1,3 | 8 (13.1) | 5 (18.5) | NS | |
vacA subtype1 | ||||
s1 | 65 | 35 (50.7) | 30 (100) | < 0.0001 |
s2 | 34 | 34 (49.3) | 0 | |
m1 | 42 | 19 (27.5) | 23 (76.7) | < 0.0001 |
m2 | 57 | 50 (72.5) | 7 (23.3) | |
s1m1 | 42 | 19 (27.5) | 23 (76.7) | < 0.0001 |
s1m2 | 23 | 16 (23.2) | 7 (23.3) | |
s2m2 | 34 | 34 (49.3) | 0 |
- Citation: Link A, Langner C, Schirrmeister W, Habendorf W, Weigt J, Venerito M, Tammer I, Schlüter D, Schlaermann P, Meyer TF, Wex T, Malfertheiner P. Helicobacter pylori vacA genotype is a predominant determinant of immune response to Helicobacter pylori CagA. World J Gastroenterol 2017; 23(26): 4712-4723
- URL: https://www.wjgnet.com/1007-9327/full/v23/i26/4712.htm
- DOI: https://dx.doi.org/10.3748/wjg.v23.i26.4712