Helicobacter pylori vacA genotype is a predominant determinant of immune response to Helicobacter pylori CagA

Table 2 Characteristics of Helicobacter pylori strains in CagA IgG dependent status of the host n (%)

	Total	H. pylori +CagA-IgG-	H. pylori +CagA-IgG+	P value
Total	99	69 (69.7)	30 (30.3)
cagA gene1				NS
Positive	93	63 (91.3)	30 (100)
Negative	6	6 (8.7)	0
cagA mRNA2	87	60	27	< 0.0001
Positive	61	34 (56.7)	27 (100)
Negative	26	26 (43.3)	0 (0)
EPIYA motifs				NS
Negative	5	5 (7.2)	0
AB	4	2 (2.9)	2 (6.7)
ABC	33	21 (30.4)	12 (40)
ABCC	7	6 (8.7)	1 (3.3)
ABCCC	2	1 (14.5)	1 (3.3)
Mixed	48	34 (49.3)	14 (46.7)
VacA-IgG1,3		8 (13.1)	5 (18.5)	NS
vacA subtype1
s1	65	35 (50.7)	30 (100)	< 0.0001
s2	34	34 (49.3)	0
m1	42	19 (27.5)	23 (76.7)	< 0.0001
m2	57	50 (72.5)	7 (23.3)
s1m1	42	19 (27.5)	23 (76.7)	< 0.0001
s1m2	23	16 (23.2)	7 (23.3)
s2m2	34	34 (49.3)	0

¹Six patients with evidence for different/mixed cagA⁺/cagA^- or vacA strains in corpus and antrum have been included to the potentially more pathogenic group for simplicity;

²RNA analyses were possible only in 87 patients/strains;

³Eighty-eight samples were available for VacA-IgG analyses. NS: Not significant, P > 0.05.