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©The Author(s) 2017.
World J Gastroenterol. Jul 14, 2017; 23(26): 4712-4723
Published online Jul 14, 2017. doi: 10.3748/wjg.v23.i26.4712
Published online Jul 14, 2017. doi: 10.3748/wjg.v23.i26.4712
Table 1 Characteristics of patients with active Helicobacter pylori infection regarding patient’s CagA-IgG status n (%)
| Total | H. pylori + CagA-IgG- | H. pylori + CagA-IgG+ | P value | |
| Total | 99 | 69 (69.7) | 30 (30.3) | |
| Gender | NS | |||
| Female | 72 | 51 (73.9) | 21 (70) | |
| Male | 27 | 18 (26.1) | 9 (30) | |
| Age | ||||
| mean ± SD | 54.1 ± 14.1 | 53.7 ± 13.7 | 55.1 ± 15.0 | NS |
| H. pylori status | ||||
| Anti-H.pylori-IgG+ | 93 | 64 (92.8) | 29 (96.7) | NS |
| Anti-CagA-IgG+ | 30 | - | 30 (100) | |
| mean CagA-IgG EIU | 1.5 ± 1.7 | 39.6.5 ± 31.1 | < 0.0001 | |
| Culture+ | 99 | 69 (100) | 30 (100) | NS |
| Histology+ | 79 | 55 (79.7) | 24 (80) | NS |
| Clinical phenotype | ||||
| Chronic active Gastritis (any severity) | 92 | 63 (91.3) | 29 (96.7) | NS |
| Chronic non-active Gastritis (grade > 2)1 | 7 | 6 (8.7) | 1 (3.3) | NS |
| Corpus predominant gastritis | 5 | 0 (0) | 5 (16.7) | 0.0020 |
| Antrum-/pangastritis | 87 | 63 (91.3) | 24 (80) | NS |
| Chronic atrophic gastritis (any severity) | 46 | 25 (36.2) | 21 (70) | 0.0023 |
| Chronic atrophic gastritis (> 2/3)1 | 28 | 14 (20.3) | 14 (46.7) | 0.014 |
| Intestinal metaplasia (any) | 23 | 12 (17.4) | 11 (36.7) | 0.068 |
| Gastric cancer | 6 | 2 (2.9) | 4 (13.3) | 0.056 |
| PUD or MALT-Lymphoma (any) | 5 | 4 (5.8) | 1 (3.3) | NS |
| Normal mucosa (no PMNs and ≤ 1 chronicity)1 | 4 | 4 (5.8) | 0 (0) | NS |
- Citation: Link A, Langner C, Schirrmeister W, Habendorf W, Weigt J, Venerito M, Tammer I, Schlüter D, Schlaermann P, Meyer TF, Wex T, Malfertheiner P. Helicobacter pylori vacA genotype is a predominant determinant of immune response to Helicobacter pylori CagA. World J Gastroenterol 2017; 23(26): 4712-4723
- URL: https://www.wjgnet.com/1007-9327/full/v23/i26/4712.htm
- DOI: https://dx.doi.org/10.3748/wjg.v23.i26.4712