Anti-inflammatory and anti-apoptotic effects of rosuvastatin by regulation of oxidative stress in a dextran sulfate sodium-induced colitis model

Figure 4 Rosuvastatin attenuated the expression of 8-OHdG and NOX1, but not of NOX2, in a dextran sodium sulphate-induced colitis model. A: 8-OHdG expression in colon sections from DSS-induced colitis mice treated with and without rosuvastatin by immunohistochemistry. 8-OHdG expression was attenuated in the rosuvastatin-treated group. Magnification × 10; B: NOX1 and NOX2 expression in colon sections from DSS-induced colitis mice treated with and without rosuvastatin by immunofluorescence. NOX1 expression was attenuated in the rosuvastatin-treated group. NOX2 expression levels were not different in DSS-induced colitis mice and control mice. Magnification × 10. DSS: Dextran sodium sulphate; 8-OHdG: 8-hydroxy-2’-deoxyguanosine; NOX: NADPH oxidase.