Functional lipidomics in patients on home parenteral nutrition: Effect of lipid emulsions

Table 1 Characteristics of the study groups

	OO-IVLE	SMOF-IVLE	No-IVLE	HC	P value (4 groups)	P value (OO vs SMOF)
Demographic, anthropometric and disease characteristics
N of subjects (M/F)	15 (8/7)	8 (3/5)	8 (2/6)	42 (19/23)	0.4051
Age (yr) median (range)	56 (19-78)	44 (19-73)	56 (29-64)	46 (16-78)	0.4051
BMI (kg/m2) median (range)	22 (12-25)	20 (17-23)	21 (16-29)	22 (17-26)	0.1407
Cause of CIF n (%)					0.0791
SBS	9 (60)	5 (62)	8 (100)
Fistulas	-	2 (25)	-
Dysmotility	5 (33)	1 (12)	-
Mucosal disease	1 (7)	-	-
Primary disease n (%)					0.0037
Mesenteric ischemia	6 (40)	1 (12)	1 (12)			0.0627
CIPO	5 (32)	1 (12)	4 (50)
Crohn’s disease	1 (7)	3 (36)	3 (38)
Others	3 (21)	3 (36)
Home parenteral nutrition schedule and oral feeding characteristics
HPN schedule: median (range)
Duration (mo)	65 (2-261)	29 (5-53)	17 (6-278)		0.2765	-
Current duration (mo)	26 (2-96)	7 (5-14)	7 (2-19)		0.0620	0.5682
Infusions (n/wk)	7 (3.5-7)	7 (2-7)	7 (2-7)		0.8028
Lipids (n inf/wk)	7 (3.5-7)	7 (2-7)	-		-	0.6946
(g/inf)	48 (26-60)	45 (28-56)	-		-	0.8601
(g/kg of BW/inf)	0.79 (0.38-1.10)	0.86 (0.43-1.20)	-		-	0.6260
(g/wk)	210 (100-406)	203 (180-350)	-		-	0.8210
Glucose (g/inf)	169 (84-350)	198 (115-375)	150 (36-265)		0.3370	-
(g/kg of BW/inf)	3.3 (1.4-5.5)	3.8 (2.4-5.8)	2.3 (0.9-5.0)		0.5959	-
(g/wk)	1014 (300-2450)	1382 (473-2625)	1050 (300-1855)		0.4265	-
Amino acids (g/inf)	50 (24-106)	61 (50-100)	29 (0-72)		0.0553	0.2070
Energy (Kcal/inf)	1400 (739-2104)	1544 (837-2180)	700 (144-1345)		0.0117	0.4578
(Kcal/BEE × 100)1	99% (26%-149%)	122% (59%-147%)	54% (7%-116%)		0.0568	0.4114
Oral feeding: median (range)
Intake (Kcal/d)	1510 (0-2657)	1071 (0-2827)	1834 (930-2965)		0.1114	-
Fat Absorption (% ingested)	38 (0-88)	27 (0-68)	71 (21-95)		0.1816	-

¹Calculated by: [(Kcal/infusion × weekly frequency of infusions/7)/basal energy expenditure (BEE)] × 100. IVLE: Intravenous lipid emulsion; OO-IVLE group: Patients receiving a PN admixture containing Clinoleic 20%; SMOF-IVLE group: Patients receiving a PN admixture containing SMOF lipid ^®20%; No-IVLE group: Patients receiving PN without IVLE; HC: Healthy controls; BMI: Body mass index; CIF: Chronic intestinal failure; BW: Body weight; SBS: Short bowel syndrome; CIPO: Chronic Intestinal Pseudo-obstruction; HPN: Home Parenteral Nutrition; Current duration: Duration of current parenteral nutrition admixture prescription.