Hepatitis C virus NS5A region mutation in chronic hepatitis C genotype 1 patients who are non-responders to two or more treatments and its relationship with response to a new treatment

Table 4 Number of mutations, according to the response to antiviral treatment

Treatments according to response, n = 134	SVR, n = 46	R, n = 29	pVR, n = 10	NR, n = 49	P value1
PKRBD mutations	5.82 ± 3.06	5.1 ± 2.3	4.9 ± 1.8	5.12 ± 2.2	n.s.
ISDR mutations	2.65 ± 2.5	1.38 ± 1.82	1.5 ± 1.3	1.6 ± 1.7	0.029

¹Kruskal-Wallis;

²SVR vs R: P = 0.025, Mann-Whitney U. This analysis excluded treatments for which the NVR type was unknown and samples that were not amplified (n = 134). NR: Null responders; NVR: No virological response; pVR: Partial virological response; SVR: Sustained virological response; PKRBD: PKR binding domain; ISDR: Interferon-sensitivity-determining region.