Expression and role of nuclear receptor coregulators in colorectal cancer

doi:10.3748/wjg.v23.i25.4480

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Jul 7, 2017; 23(25): 4480-4490
Published online Jul 7, 2017. doi: 10.3748/wjg.v23.i25.4480

Table 4 Effects of the different nuclear receptors coregulators on the WNT signaling pathway

Coregulator	Effect	Assay	Domains on β-catenin	Ref.
NCoA-1	↑	GPD CoIP	aa 234-585	Li 2004, Tong 2015
NCoA-2	↓	GPD	C-terminal part (aa)	Li 2004, Song 2005, Yu 2016
CREBBP	↑	Y2H GPD CoIP	AR10 to C-ter	Takemaru 2000
N-CoR1		GPD	aa 120-683	Song 2008
N-CoR2		GPD	aa 120-683	Song 2008
NRIP1	↓	CoIP		Zhang 2014

Y2H: Yeast two-hybrid assay; CoIP: Coimmunoprecipitation assay; GPD: GST-pull down assay; AR: Armadillo repeat.

Citation: Triki M, Lapierre M, Cavailles V, Mokdad-Gargouri R. Expression and role of nuclear receptor coregulators in colorectal cancer. World J Gastroenterol 2017; 23(25): 4480-4490
URL: https://www.wjgnet.com/1007-9327/full/v23/i25/4480.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i25.4480