Expression and role of nuclear receptor coregulators in colorectal cancer

Table 3 Mutations identified in the different nuclear receptor coregulator genes in human colorectal cancer n (%)

Coregulator	216 United States patients (COAD-US)		187 Chinese patients (COCA-CN)
	Patients affected	Mutations	Patients affected	Mutations
NCOA1	6 (2.78)	7	9 (4.81)	14
NCOA2	10 (4.63)	10	26 (13.90)1	32
NCOA3	21 (9.72)1	17	9 (4.81)	10
NCOA6	19 (8.80)1	21	8 (4.28)	10
PPARGC1A	10 (4.63)	12	5 (2.67)	6
EP300	13 (6.02)1	15	14 (7.49)1	21
CREBBP	18 (8.33)1	20	7 (3.74)	11
MED1	3 (1.39)	4	6 (3.21)	6
NCOR1	21 (9.72)1	25	23 (12.30)1	48
NCOR2	41 (18.98)1	43	30 (16.04)1	40
NRIP1	5 (2.31)	5	6 (3.21)	10
MTA1	11 (5.09)1	11	12 (6.42)1	13

Data from the ICGC Data Portal (https://dcc.icgc.org).

¹Indicated genes with mutations detected in more than 5% of patients.