Expression and role of nuclear receptor coregulators in colorectal cancer

doi:10.3748/wjg.v23.i25.4480

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 7, 2017; 23(25): 4480-4490
Published online Jul 7, 2017. doi: 10.3748/wjg.v23.i25.4480

Table 2 Copy number variation and expression levels of nuclear receptor coregulators in human colorectal cancer

Coregulator	CNV (%)	Expression	Ref.
NCOA1	Gain (5.5)	ND
NCOA2	Gain (30.1)	↑ or ↓	Giannini 2005, Grivas 2009, Yu 2016
NCOA3	Gain (40.6)	↑	Anzick 1997, Aust 2004, Xie 2005
NCOA6	Gain (42.7)	↑	Lee 1999
PPARGC1A	Loss (8.4)	↓	D’Errico 2011
EP300	Loss (19.3)	↑	Ishihama 2007
CREBBP	Gain (5.3)	↑	Ishihama 2007
MED1	Gain (11.8) Loss (8.4)	↓	Giannini 2005
NCOR1	Loss (40.4)	↑	Fernández-Majada 2007
NCOR2	Gain (9.8)	↑	Giannini 2005, Fernández-Majada 2007
NRIP1	Loss (17.2)	↓	Lapierre 2014
MTA1	Loss (15.0)	↑	Toh 1997

Gene copy number analysis was performed in 379 CRC samples from the “Carte d’Identité des Tumeurs de la Ligue contre le Cancer” using the Nexus Copy Number software (BioDiscovery, CA, United States). The percentage of CRC specimens showing chromosomic gains and losses are indicated (B. Orsetti, personal communication). Variations in the expression level were determined using the data extracted from the indicated references. ND: Not determined; CRC: Colorectal cancer.

Citation: Triki M, Lapierre M, Cavailles V, Mokdad-Gargouri R. Expression and role of nuclear receptor coregulators in colorectal cancer. World J Gastroenterol 2017; 23(25): 4480-4490
URL: https://www.wjgnet.com/1007-9327/full/v23/i25/4480.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i25.4480