Gastric cancer-derived heat shock protein-gp96 peptide complex enhances dendritic cell activation

Figure 3 Activity of natural killer cells assayed in the presence of gp96-peptide complexes. At an effector to target cell ratio of 10:1, natural killer cells were incubated with three different gastric cancer (GC) cell strains in the presence of 1, 2 and 5 μg/mL gp96-peptide complexes or gp96 purified from Ad-gp96 expression. NK cell activity for (A) KATOIII, (B) MKN-28 and (C) SGC-7901 cells incubated with gp96-peptide complexes (gp96K-Pep, gp96M-Pep and gp96S-Pep) vs GC cell source antigen peptide (K-Pep, M-Pep and S-Pep) for each of the three cell lines, respectively. ^aP < 0.05.