Risk factors for metachronous gastric carcinoma development after endoscopic resection of gastric dysplasia: Retrospective, single-center study

Table 5 Analysis of risk factors associated with occurrence of metachronous carcinoma n (%)

	Control group(n = 488)	Metachronous carcinoma group (n = 27)	Univariate analysisP value	Multivariate analysis
				OR	95%CI	P value
Sex			0.005			0.027
Male	328 (67.2)	25 (92.6)		5.238	1.211-22.661
Female	160 (32.8)	2 (7.4)		1.000
Age			0.671
≥ 60	343 (70.3)	18 (66.7)
< 60	145 (29.7)	9 (33.3)
Dysplasia			0.024			0.023
Low grade	417 (85.5)	18 (66.7)		1.000
High grade	71 (14.5)	9 (33.3)		2.741	1.148-6.546
En bloc resection	179 (37.7)	9 (33.3)	0.839
Intestinal metaplasia	155 (31.8)	9 (33.3)	0.005	2.647	1.165-6.012	0.020
Atrophy			0.010			0.065
Closed	445 (91.2)	20 (74.1)		1.000
Open	43 (8.8)	7 (25.9)		2.492	0.946-6.569
Resection method			0.503
EMR	359 (73.6)	18 (66.7)
ESD	129 (26.4)	9 (33.3)
Endoscopic findings			0.546
Elevated	326 (66.8)	21 (77.8)
Flat	96 (19.7)	3 (11.1)
Depressed	66 (13.5)	3 (11.1)
Location			1.000
Lower	324 (66.4)	17 (63.0)
Mid	156 (32.0)	9 (33.3)
Upper	8 (1.6)	0 (0.0)
Size			0.532
≤ 3	334 (68.4)	17 (63.0)
> 3	154 (31.6)	10 (37.0)
Helicobacter Pylori infection	385 (78.9)	20 (74.1)	0.629