Risk factors for metachronous gastric carcinoma development after endoscopic resection of gastric dysplasia: Retrospective, single-center study

Table 4 Analysis of clinical factors associated with occurrence of metachronous lesions n (%)

	Control group	Metachronous group	Univariate analysis	Multivariate analysis
	(n = 488)	(n = 91)	P value	OR	95%CI	P value
Sex			0.002			0.005
Male	328 (67.2)	76 (83.5)		2.314	1.281-4.179
Female	160 (32.8)	15 (16.5)		1.000
Age			0.174
≥ 60	343 (70.3)	70 (76.9)
< 60	145 (29.7)	21 (23.1)
Dysplasia			0.059
Low grade	417 (85.5)	70 (76.9)
High grade	71 (14.5)	21 (23.1)
En bloc resection	179 (37.7)	32 (35.2)	0.813
Intestinal metaplasia	155 (31.8)	45 (49.5)	0.002	1.915	1.203-3.049	0.006
Atrophy			0.022			0.103
Closed	445 (91.2)	75 (82.4)		1.000
Open	43 (8.8)	16 (17.6)		1.708	0.897-3.252
Resection method			0.897
EMR	359 (73.6)	66 (72.5)
ESD	129 (26.4)	25 (27.5)
Endoscopic findings			0.665
Elevated	326 (66.8)	64 (70.3)
Flat	96 (19.7)	18 (19.8)
Depressed	66 (13.5)	9 (9.9)
Location			0.172
Lower	324 (66.4)	52 (57.1)
Mid	156 (32.0)	38 (41.8)
Upper	8 (1.6)	1 (1.1)
Size			0.394
≤ 3	334 (68.4)	58 (63.7)
> 3	154 (31.6)	33 (36.3)
Helicobacter Pylori infection	385 (78.9)	66 (72.5)	0.210