Maytenus erythroxylon Reissek (Celastraceae) ethanol extract presents antidiarrheal activity via antimotility and antisecretory mechanisms

Table 5 Effect of oral administration of EtOHE-Me and loperamide on castor oil induced-diarrhea in mice

Treatment,as p.o.	Dose in mg/kg	Evacuation index	Wet feces	Inhibition of diarrhea
NaCl 0.9%	-	21 (19-25)	47%	-
Loperamide	5	0 (0-4)2	0%	100%
EtOHE-Me	62.5	8 (5-11)1	4%	62%
	125	7 (6-8)1	2%	66%
	250	6.5 (3-7)1	0%	69%
	500	4 (3-5)13	0%	81%

¹Significant differences between treated groups vs NaCl 0.9% control group (P < 0.05);

²Significant differences between loperamide group vs NaCl 0.9% control group (P < 0.001);

³Significant differences between EtOHE-Me 250 mg/kg vs EtOHE-Me 500 mg/kg (P < 0.05). Data are expressed as median (minimum-maximum). EtOHE-Me: Ethanol extract of Maytenus erythroxylon.