Inhibition of N-methyl-N-nitrosourea-induced gastric tumorigenesis by Liuwei Dihuang Pill in db/db mice

doi:10.3748/wjg.v23.i23.4233

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 21, 2017; 23(23): 4233-4242
Published online Jun 21, 2017. doi: 10.3748/wjg.v23.i23.4233

Table 4 Incidence of gastric dysplasia and carcinoma in the experimental mice

Group	Survival	Mortality	Histopathology findings (no. of mice)
Group	Survival	Mortality	Chronic gastritis	Gastric dysplasia	Gastric carcinoma
db/m + MNU + saline	12	0	5 (42)	2 (17)^a	0
db/db + MNU + saline	9	3 (25)	6 (67)	6 (67)	2 (22)
db/db + MNU + metformin	10	2 (17)	6 (60)	1 (10)^a	0
db/db + MNU + LDP	10	2 (17)	5 (50)	1 (10)^a	0

Data are presented as n (%).

^aP < 0.05 vs incidence of gastric dysplasia in db/db + MNU + saline group. Fisher’s exact test was used for comparison among groups. LDP: Liuwei Dihuang Pill; MNU: N-methyl-N-nitrosourea.

Citation: Zhuang S, Jian YM, Sun YN. Inhibition of N-methyl-N-nitrosourea-induced gastric tumorigenesis by Liuwei Dihuang Pill in db/db mice. World J Gastroenterol 2017; 23(23): 4233-4242
URL: https://www.wjgnet.com/1007-9327/full/v23/i23/4233.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i23.4233